Stendra contains avanafils, which relaxes muscles and increases blood flow to particular areas of the body. Avanafil is used to treat erectile dysfunction (impotence). Avanafil may also be used for purposes not listed in this medication guide.
Stendra (Avanafil) is a used to treat men who have erectile dysfunction, also referred to as sexual impotence. Stendra is the first and only drug approved by the FDA that can be used 15 minutes before sexual intercourse. Note that Stendra does not offer protection against sexually transmitted diseases such as hepatitis B, gonorrhea, HIV, and syphilis.
Stendra is categorized under a class of medications known as phosphodiesterase 5 (PDE5) inhibitors. Stendra works by slowing down the activities of an enzyme known as phosphodiesterase type-5. The penis is one of the body parts where this enzyme works. To understand how Stendra works, it is imperative to look at the way erection occurs.
Erection of the penis is brought about by the filling of the penis with blood. The filling happens because the blood vessels transporting blood to the penis increase in size while the vessels taking blood away from the penis decrease in size. The sexual stimulation that causes an erection triggers the release of nitric oxide in the penis. Nitric oxide then makes an enzyme known as guanylate cyclase to generate cyclic guanosine monophosphate (cGMP). cGMP is responsible for increasing and reducing the size of blood vessels that carry blood to and from the penis. When another enzyme, phosphodiesterase-5 compromises the activities of cGMP, the vessels regain their normal size, and the blood leaves the penis, thereby causing an erection to end.
Stendra helps restore the ability to have an erection by preventing phosphodiesterase-5 from destroying cGMP. This means that cGMP stays in the penis for longer thus causes a prolonged engorgement of the penis with blood.